Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Inhibitory Effect of Interferon on Murine Sarcoma and Leukaemia Virus Infection in vitro

Nature volume 223, pages 845–846 (1969)Cite this article

Abstract

THE interaction of tumour viruses with the interferon system has important implications for the pathogenesis of infection and transformation of cells by tumour viruses. The sensitivity of tumour viruses to interferon varies widely1–20, but at present there seems to be no marked difference in the sensitivities of DNA and RNA viruses. Viral functions reported to be inhibited by interferon are replication, virus-induced transformation and virus-specified T-antigen production in cells pretreated with interferon before virus infection. After transformation has occurred, in the case of simian virus-40 (SV40), T-antigen production and the morphology of transformation in vitro are unaffected by the antiviral action of subsequently applied interferon10,11.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Barski, G., and Cornefert, R., J. Nat. Cancer Inst., 28, 823 (1962).

    CAS  PubMed  Google Scholar 

  2. Bader, J. P., Virology, 16, 436 (1962).

    Article  CAS  Google Scholar 

  3. Strandstorm, H., Sandelin, K., and Oker-Blom, N., Virology, 16, 384 (1962).

    Article  Google Scholar 

  4. Allison, A. C., Viruses, Nucleic Acids and Cancer, 426 (Williams and Wilkins, Baltimore, 1963).

    Google Scholar 

  5. Friedman, R. M., Rabson, A. S., and Kirkman, W. R., Proc. Soc. Exp. Biol. and Med., 112, 347 (1963).

    Article  CAS  Google Scholar 

  6. Diderholm, H., Arch. Ges. Virusforsch., 14, 39 (1963).

    Article  CAS  Google Scholar 

  7. Glasgow, L. A., and Habel, K., Virology, 19, 328 (1963).

    Article  CAS  Google Scholar 

  8. Lampson, G. P., Tytell, A. A., Nemes, M. M., and Hilleman, M. R., Proc. Soc. Exp. Biol. and Med., 112, 468 (1963).

    Article  CAS  Google Scholar 

  9. Todaro, G., and Baron, S., Proc. US Nat. Acad. Sci., 54, 752 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Oxman, M. N., and Black, P. H., Proc. US Nat. Acad. Sci., 55, 1133 (1966).

    Article  ADS  CAS  Google Scholar 

  11. Oxman, M., Baron, S., Black, P. H., Takemoto, K. K., Habel, K., and Rowe, W. P., Virology, 32, 122 (1967).

    Article  CAS  Google Scholar 

  12. Baron, S., and Levy, H. B., Ann. Rev. Microbiol., 20, 291 (1966).

    Article  CAS  Google Scholar 

  13. Traub, W. H., and Morgan, H. R., Arch. Ges. Virusforsch., 20, 1 (1967).

    Article  CAS  Google Scholar 

  14. Wheelock, E. F., Proc. US Nat. Acad. Sci., 55, 774 (1966).

    Article  ADS  CAS  Google Scholar 

  15. Wheelock, E. F., Proc. Soc. Exp. Biol. and Med., 124, 855 (1967).

    Article  CAS  Google Scholar 

  16. Vandeputte, M., De Lafonteyne, J., Billiau, A., and De Somer, P., Arch. Ges. Virusforsch., 20, 235 (1967).

    Article  CAS  Google Scholar 

  17. Gresser, I., Fontaine, D., Coppey, J., Falcoff, R., and Falcoff, E., Proc. Soc. Exp. Biol. and Med., 124, 84 (1967).

    Article  CAS  Google Scholar 

  18. Gresser, I., Coppey, J., Falcoff, E., and Fontaine, D., Proc. Soc. Exp. Biol and Med., 124, 91 (1967).

    Article  CAS  Google Scholar 

  19. Gresser, I., presented at the Symposium on Interferon, Lyon, France (1969).

    Google Scholar 

  20. Oxman, M. N., and Takemoto, K. K., presented at the Symposium on Interferon, Lyon, France (1969).

    Google Scholar 

  21. Rubin, H., Viruses, Nucleic Acids and Cancer, 484 (Williams and Wilkins, Baltimore, 1963).

    Google Scholar 

  22. Sarma, P. S., Cheong, M. P., Hartley, J. W., and Huebner, R. J., Virology, 33, 180 (1967).

    Article  CAS  Google Scholar 

  23. Yoshikura, H., Hirokawa, Y., Yamada, M., and Sugano, H., Virology, 2, 85 (1968).

    CAS  Google Scholar 

  24. Ho, M., Interferon (edit. by Finter, N. B.), 25 (Wiley, New York, 1967).

    Google Scholar 

  25. Sarma, P. S., Shiu, G., Neubauer, R., Baron, S., and Huebner, R. J., Proc. US Nat. Acad. Sci., 62, 1046 (1969).

    Article  ADS  CAS  Google Scholar 

  26. Rhim, J. S., Huebner, R. J., and Gisin, S., Proc. Soc. Exp. Biol. and Med., 130, 181 (1969).

    Article  CAS  Google Scholar 

  27. Baron, S., and Buckler, C. E., Science, 141, 1061 (1963).

    Article  ADS  CAS  Google Scholar 

  28. Baron, S., Barban, S., and Buckler, C. E., Science, 145, 814 (1964).

    Article  ADS  CAS  Google Scholar 

  29. Baron, S., Buckler, C. E., Levy, H. B., and Freidman, R. M., Proc. Soc. Exp. Biol. and Med., 125, 1320 (1967).

    Article  CAS  Google Scholar 

  30. Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., Proc. US Nat. Acad. Sci., 53, 931 (1965).

    Article  ADS  CAS  Google Scholar 

  31. Hartley, J. W., Rowe, W. P., Capps, W. I., and Huebner, R. J., J. Virol., 3, 126 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Hartley, J. W., and Rowe, W. P., Proc. US Nat. Acad. Sci., 55, 780 (1966).

    Article  ADS  CAS  Google Scholar 

  33. Huebner, R. J., Hartley, J. W., Rowe, W. P., Lane, W. T., and Capps, W. I., Proc. US Nat. Acad. Sci., 56, 1164 (1966).

    Article  ADS  CAS  Google Scholar 

  34. Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).

    Article  ADS  CAS  Google Scholar 

  35. Peries, J., Canivet, M., Guillemain, G., and Boiron, M., J. Gen. Virol., 3, 465 (1968).

    Article  CAS  Google Scholar 

  36. Levy, H. B., Law, L. W., and Rabson, A. S., Proc. US Nat. Acad. Sci. (1969, in the press).

Download references

Author information

Authors and Affiliations

  1. National Institutes of Health and Microbiological Associates, Inc., Bethesda, Maryland

    PADMAN S. SARMA, GRACE SHIU, SAMUEL BARON & R. J. HUEBNER

Authors
  1. PADMAN S. SARMA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GRACE SHIU
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. SAMUEL BARON
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. J. HUEBNER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SARMA, P., SHIU, G., BARON, S. et al. Inhibitory Effect of Interferon on Murine Sarcoma and Leukaemia Virus Infection in vitro. Nature 223, 845–846 (1969). https://doi.org/10.1038/223845a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/223845a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing