THE competence of animals to respond immunologically develops for different antigens at different stages of ontogeny1. Thus C57 Bl mice do not form antibodies to sheep red blood cells (sRBC) during the first 10 days after birth even though such newborns can respond to a number of other antigens2. We and others previously demonstrated that antibody formation to sRBC can be “turned on” prematurely when newborns are given macrophages from adults at or near the time of antigen administration3,4. More recently we observed that such premature antibody formation can be achieved without the transfer of macrophages provided that the antigen is administered in conjunction with bacterial endotoxin (LPS) or double-stranded synthetic polynucleotides, agents that are known to enhance the metabolic activities of macrophages5–7.
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WINCHURCH, R., BRAUN, W. Antibody Formation: Premature Initiation by Endotoxin or Synthetic Polynucleotides in Newborn Mice. Nature 223, 843–844 (1969). https://doi.org/10.1038/223843a0
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