Immune Complexes in Mice infected neonatally with Moloney Leukaemogenic and Murine Sarcoma Viruses


SEVERAL viruses have been reported to induce immunological tolerance in mice when administered in the immediate postnatal period. Among these are the lymphocytic choriomeningitis (LCM) virus1,2 and the murine leukaemogenic viruses3–5. Moloney leukaemogenic virus (MLV) induces lymphocytic leukaemia in both newborn and adult mice6. Inoculation of adults with MLV results, however, in the development of both humoral and cell-mediated immune responses to the virus, whereas in neonatally infected mice these responses are greatly reduced or undetectable4,7.

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  1. 1

    Hotchin, J., Cold Spring Harbor Symp. Quant. Biol., 27, 479 (1962).

  2. 2

    Volkert, M., and Hannover-Larsen, J., Prog. Med. Virol., 7, 160 (1965).

  3. 3

    Axelrad, A. A., Prog. Exp. Tumour Res., 6, 30 (1965).

  4. 4

    Klein, E., and Klein, G., Nature, 209, 163 (1966).

  5. 5

    Chieco-Bianchi, L., Tridente, G., Pennelli, N., and Fiore-Donati, L., Bibl. Haemat., 31, 40 (1968).

  6. 6

    Moloney, J. B., Nat. Cancer Inst. Monog., 4, 7 (1960).

  7. 7

    Klein, E., and Klein, G., Cancer Res., 25, 851 (1965).

  8. 8

    Oldstone, M. B. A., and Dixon, F. J., Science, 158, 1193 (1967).

  9. 9

    Oldstone, M. B. A., and Dixon, F. J., J. Exp. Med., 129, 483 (1969).

  10. 10

    Harvey, J. J., J. Gen. Virol., 3, 327 (1968).

  11. 11

    Guttman, P. H., and Kohn, H. I., Amer. J. Pathol., 37, 293 (1960).

  12. 12

    Hirsch, M. S., and Harvey, J. J., Intern. J. Cancer (in the press).

  13. 13

    Notkins, A. L., Mahar, S., Scheele, C., and Goffman, J., J. Exp. Med., 124, 81 (1966).

  14. 14

    Hirsch, M. S., Murphy, F. A., and Hicklin, M. D., J. Exp. Med., 127, 757 (1968).

  15. 15

    Recher, L., Tanaka, T., Sykes, J. A., Yumoto, T., Seman, G., Young, L., and Dmochowski, L., Nat. Cancer Inst. Monog., 22, 459 (1966).

  16. 16

    Dunn, T. B., and Green, A. W., J. Nat. Cancer Inst., 36, 987 (1966).

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HIRSCH, M., ALLISON, A. & HARVEY, J. Immune Complexes in Mice infected neonatally with Moloney Leukaemogenic and Murine Sarcoma Viruses. Nature 223, 739–740 (1969).

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