Multiple Forms of Rat Brain Monoamine Oxidase

  • A Corrigendum to this article was published on 23 August 1969

Abstract

THE enzyme monoamine oxidase (monoamine : O2 oxido-reductase (deaminating), EC 1.4.3.4) (MAO) is likely to be concerned in the metabolism of known or suspected central nervous system transmitters such as nor adrenaline, dopamine and 5-hydroxytryptamine. In the therapy of depressive disease, drugs are used which are able to inhibit MAO and it is thought that they owe their beneficial effect to this ability and to the resulting accumulation of amines. It is found, however, that some compounds belonging to this group are considerably more effective therapeutically than others1,2 and no fully satisfactory explanation has been offered. We now offer an approach which we think in better accord with the characteristics of MAO.

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YOUDIM, M., COLLINS, G. & SANDLER, M. Multiple Forms of Rat Brain Monoamine Oxidase. Nature 223, 626–628 (1969). https://doi.org/10.1038/223626a0

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