Abstract
Radioactive RNA introduced into “target” cells can be induced to form hybrids with nuclear DNA. The location of these hybrids can be detected by autoradiography.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dubnau, D., Smith, I., and Marmur, J., Proc. US Nat. Acad. Sci., 54, 724 (1965); Smith, I., Dubnau, D., Morell, P., and Marmur, J., J. Mol. Biol., 33, 123 (1968); Oishi, M., Oishi, A., and Sueoka, N., Proc. US Nat. Acad. Sci., 55, 1095 (1966).
Geiduschek, E. P., Snyder, L., Colvill, A. J. E., and Sarnat, M. J., Mol. Biol., 19, 541 (1966); Taylor, K., Hradecna, Z., and Szybalski, W., Proc. US Nat. Acad. Sci., 57, 1618 (1967); Cohen, S. N., and Hurwitz, J., Proc. US Nat. Acad. Sci., 57, 1759 (1967).
Spiegelman, S., and Yankofsky, S. A., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel, H. J.), 537 (Academic Press, New York, 1965).
Birnstiel, M., Wallace, H., Sirlin, J., and Fischberg, M., Nat. Cancer Inst. Monog., 23, 431 (1966).
Hennig, W., J. Mol. Biol., 38, 227 (1968).
Britten, R. J., and Kohne, D. E., Carnegie Institution Yearbook, 78 (1966/7); Wetmur, J. G., and Davidson, N., J. Mol. Biol., 31, 349 (1968).
Scherrer, K., and Darnell, J. E., Biochem. Biophys. Res. Commun., 7, 486 (1962).
Loening, U. E., Biochem. J., 102, 251 (1967).
Birnstiel, M., Speirs, J., Purdom, I., Jones, K., and Loening, U. E., Nature, 219, 454 (1968).
Yankofsky, S. A., and Spiegelman, S., Proc. US Nat. Acad. Sci., 51, 1197 (1964).
Flamm, W. G., Bond, H. E., and Burr, H. E. Biochem. Biophys. Acta, 129, 310 (1966).
Nygaard, A. P., and Hall, B. D., Biochem. Biophys. Res. Commun., 12, 98 (1963).
Perry, R. P., in Methods in Cell Physiology (edit. by Prescott, D. M.), 1, 324 (Academic Press, New York, 1964).
Huang, R. C., and Bonner, J., Proc. US Nat. Acad. Sci., 48, 1216 (1962).
Murray, K., Ann. Rev. Biochem., 34, 209 (1965).
Frenster, J. H., Nature, 206, 680 (1965).
Bonner, J., Dahmus, M. E., Fambrough, D., Huang, R. C., Marushige, K., and Tuan, D. Y. H., Science, 159, 47 (1968).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).
Macgregor, H. C., J. Cell. Sci., 3, 437 (1968).
Gall, J. G., Genetics (in the press).
Gall, J. G., and Pardue, M. L., Proc. US Nat. Acad. Sci. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JOHN, H., BIRNSTIEL, M. & JONES, K. RNA-DNA Hybrids at the Cytological Level. Nature 223, 582–587 (1969). https://doi.org/10.1038/223582a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/223582a0
This article is cited by
-
Extrachromosomal circular DNA: a new potential role in cancer progression
Journal of Translational Medicine (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
