Active Immunization of Children suffering from Acute Leukaemia in Acute Phase with “Live” Allogeneic Leukaemic Cells

Abstract

IN attempting to influence immunologically the leukaemic process, we have assumed that the immunological system of the patient suffering from leukaemia and tumours is tolerant to the leukaemogenic agent in his own tissue (a leukaemic cell or virus), and thus to the oncogenic agent (a tumour cell). Vertical transmission of the leukaemogenic profactor with the subsequent transformation to the active agent may be involved, as in the case of Gross leukaemia in mice1. It is also possible that there is specific suppression of the particular clones of mature lymphocytes which are antileukaemic or antitumorigenic in normal conditions. Clearly, immunological restoration can be achieved in patients suffering from leukaemia or tumours by overcoming the immunological tolerance to a leukaemogenic or an oncogenic agent2–9.

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References

  1. 1

    Gross, L., Cancer, 6, 153 (1968).

  2. 2

    Skurkovich, S. V., in Forty-first Conf. Scientific Council of the Central Inst. Hematol. and Blood Transfusion, 3 (Moscow, 1964, in Russian).

  3. 3

    Skurkovich, S. V., Rutberg, P. A., Machonova, L. A., and Maller, A. R., in The Problems of Hematology and Blood Transfusion, 2, 23 (in Russian, 1965).

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    Skurkovich, S. V., in The Problems of Hematology and Blood Transfusion, 5, 56 (Moscow, 1965, in Russian).

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    Skurkovich, S. V., in The Present Problems of Hematology and Blood Transfusion, 38, 25 (Moscow, 1967, in Russian).

  6. 6

    Skurkovich, S. V., Machonova, L. A., Reznichenko, F. M., and Chervonski, G. I., in The Problems of Hematology and Blood Transfusion, 11, 18 (in Russian, 1967).

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    Skurkovich, S. V., in The Problems of Leukemia, 178 (Moscow, 1967).

  8. 8

    Skurkovich, S. V., Kislyak, N. S., and Machonova, L. A., in Forty-third Scientific Council Central Inst. Hematol. and Blood Transfusion, 1, 22 (Moscow, 1967, in Russian).

  9. 9

    Skurkovich, S. V., in The Problems of Hematology and Blood Transfusion, 3, 33 (in Russian, 1968).

  10. 10

    Moore, G. E., Ito, E., Ulrich, K., and Sandberg, A. A., Cancer, 19, 5 (1966).

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SKURKOVICH, S., KISLJAK, N., MACHONOVA, L. et al. Active Immunization of Children suffering from Acute Leukaemia in Acute Phase with “Live” Allogeneic Leukaemic Cells. Nature 223, 509–511 (1969). https://doi.org/10.1038/223509a0

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