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Functional Significance of the Sympathetic Nervous System in Production of Hypertension

Abstract

SEVERAL studies have implicated the sympathetic nervous system in the induction and maintenance of hypertension1–6. Other reports7,8 have shown that hypertension can be produced even after destruction of the sympathetic nervous system by immunosympathectomy. Treatment with anti-nerve growth factor9 results in a sub-total sympathectomy which is irreversible. Dahl has developed a method of accelerating production of salt hypertension by using L-triiodothyronine (T3) (ref. 10). Using this technique for producing hypertension, we have evaluated the functional significance of the sympathetic nervous system during induction of T3 and NaCl hypertension.

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WILLARD, P., FULLER, R. Functional Significance of the Sympathetic Nervous System in Production of Hypertension. Nature 223, 417–418 (1969). https://doi.org/10.1038/223417a0

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