Abstract
CALCIUM cyclamate is widely used as a sweetening agent in foods and beverages. We now find that oral administration of calcium cyclamate to hamsters induces myocardial lesions accompanied by coronary sclerosis as well as soft-tissue calcification in other organs. This adverse effect of calcium cyclamate overdosage remained unnoticed in earlier toxicological tests1–3 and it seems from our present studies that cyclamate may enhance the potentially toxic actions of the cation with which it forms a stable, water-soluble salt.
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BAJUSZ, E. Myocardial Lesions: A Reassessment of the Toxicology of Calcium Cyclamate. Nature 223, 406–407 (1969). https://doi.org/10.1038/223406a0
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DOI: https://doi.org/10.1038/223406a0
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