Abstract
THE fibrinogen molecule from several mammals is made up of three different peptide chains1,2, the α(A), β(B) and γ chains, which are cross-linked by disulphide bonds and possibly other bonds3–6. Previous comparative studies of the primary structure of fibrinogen have dealt with its N-terminal amino-acids2 and with amino-acid sequences of fibrinopeptides A and B, released from amino termini of the respective chains by the action of thrombin7. These have shown considerable interspecies variation in amino-acid sequences of the fibrinopeptides, except for a relatively constant C-terminal sequence in the fibrino-peptide A. We now report a second relatively constant sequence in the fibrinogen molecule, the amino terminus of its γ-chain.
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PIRKLE, H., HENSCHEN, A. & POTAPOUS, A. Interspecies Constancy of N-Terminal Amino-acid Sequences in the γ-Chain of Fibrinogen. Nature 223, 400–401 (1969). https://doi.org/10.1038/223400a0
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DOI: https://doi.org/10.1038/223400a0
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