Abstract
LEUCOCYTE glycogen content and leucocyte alkaline phosphatase activity (LAP) usually vary in parallel. Both are increased in acute infections and polycythaemia vera1,2, in pregnancy3,4 and after administration of oestrogen5. Similarly, there is little of either glycogen or LAP in chronic granulocytic leukaemia1,2. There is known to be more LAP than normal in Down's syndrome6, and so we have measured leucocyte glycogen to find out whether the situation is the same.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Valentine, W. N., and Beck, W. S., J. Lab. Clin. Med., 38, 39 (1951).
Valentine, W. N., Follette, J. H., and Lawrence, J. S., J. Clin. Invest., 32, 251 (1953).
Pritchard, J. A., J. Lab. Clin. Med., 50, 432 (1951).
Abul-Fadl, Y., and Scott, R. B., Scand. J. Haematol. (in the press).
Ebadi, M., and McCoy, E. E., Biochim. Biophys. Acta, 130, 502 (1966).
Alter, A. A., Lee, S. L., Pourfar, M., and Dobkin, G., J. Clin. Invest., 41, 1341 (1962).
Scott, R. B., J. Clin. Invest., 47, 344 (1968).
Kaplow, L. S., Blood, 10, 1023 (1955).
Scott, R. B., New Engl. J. Med., 278, 1436 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ABUL-FADL, Y., SCOTT, R. Increased Leucocyte Glycogen in Down's Syndrome. Nature 223, 310–311 (1969). https://doi.org/10.1038/223310a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/223310a0
This article is cited by
-
On the influence of age on immunity in Down's syndrome
European Journal of Pediatrics (1977)
-
Defects in granulocyte function in various chromosome abnormalities (down's-, edwards'-, cri-du-chat syndrome)
Klinische Wochenschrift (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
