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Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro

Abstract

WHOLE body X-irradiation depresses or enhances the antibody response depending on the dosage and its temporal relationship to injection of antigen in the animal1. Using organ cultures of rabbit lymph nodes, we succeeded in initiating both primary and secondary types of antibody response to bacteriophage φX 174 in vitro2,3. The experiments reported here (a) test this in vitro system for its use in the study of radiation effects on the antibody response, (b) further elucidate the mechanisms of radiation-induced enhancement of the primary antibody response, and (c) compare radiosensitivity of primary and secondary responses initiated in the cultures.

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TAO, TW., LEARY, P. Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro. Nature 223, 306–308 (1969). https://doi.org/10.1038/223306a0

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