Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro


WHOLE body X-irradiation depresses or enhances the antibody response depending on the dosage and its temporal relationship to injection of antigen in the animal1. Using organ cultures of rabbit lymph nodes, we succeeded in initiating both primary and secondary types of antibody response to bacteriophage φX 174 in vitro2,3. The experiments reported here (a) test this in vitro system for its use in the study of radiation effects on the antibody response, (b) further elucidate the mechanisms of radiation-induced enhancement of the primary antibody response, and (c) compare radiosensitivity of primary and secondary responses initiated in the cultures.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Taliaferro, W. H., Taliaferro, L. G., and Jaroslow, B. N., Radiation and Immune Mechanisms (Academic Press, NY, and London, 1964).

    Google Scholar 

  2. 2

    Tao, T. W., and Uhr, J. W., Science, 151, 1096 (1966).

    ADS  Article  CAS  Google Scholar 

  3. 3

    Tao, T. W., J. Immunol., 101, 1253 (1968).

    PubMed  CAS  Google Scholar 

  4. 4

    Tao, T. W., and Hertig, A. T., Amer. J. Anat., 116, 315 (1965).

    Article  CAS  Google Scholar 

  5. 5

    Adams, M. H., Bacteriophages (Interscience Publishers, Inc., NY, 1959).

    Google Scholar 

  6. 6

    Pribnow, J. G., and Silverman, M. S., J. Immunol., 98, 225 (1967).

    PubMed  CAS  Google Scholar 

  7. 7

    Taliaferro, W. H., and Jaroslow, B. N., J. Infect. Dis., 107, 341 (1960).

    Article  CAS  Google Scholar 

  8. 8

    Dixon, F. J., and McConahey, P. J., J. Exp. Med., 117, 833 (1963).

    Article  CAS  Google Scholar 

  9. 9

    Makinodan, T., Kastenbaum, M. A., and Peterson, W. J., J. Immunol., 88, 31 (1962).

    CAS  Google Scholar 

  10. 10

    Stecher, V. J., and Thorbecke, G. J., J. Exp. Med., 125, 33 (1967).

    Article  CAS  Google Scholar 

Download references

Author information



Rights and permissions

Reprints and Permissions

About this article

Cite this article

TAO, TW., LEARY, P. Radiation-induced Depression of Primary and Secondary Antibody Responses to Bacteriophage φX 174 in vitro. Nature 223, 306–308 (1969).

Download citation


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing