Letter | Published:

Chloroma Regression induced by the Granulocytic Chalone

Nature volume 222, pages 995996 (07 June 1969) | Download Citation

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Abstract

IT has been demonstrated recently that in four different malignant tumours cells responded by mitotic inhibition to their own tissue-specific chalone when the chalone content was artificially increased either in vitro or in vivo1–3. It has also been shown that when extracts containing melanocyte chalone1 were injected into animals bearing malignant melanomata, the tumours regressed3. We have tried to treat malignant chloroma in rats by means of the granulocytic chalone.

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References

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Affiliations

  1. II Department of Pathology, University of Helsinki, Helsinki, Finland.

    • T. RYTÖMAA
    •  & KYLLIKKI KIVINIEMI

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DOI

https://doi.org/10.1038/222995a0

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