Letter | Published:

Increased Bilirubin Conjugation in Heterozygous Gunn Rats treated with Phenobarbital

Nature volume 222, pages 990991 (07 June 1969) | Download Citation

Subjects

Abstract

THE mechanism by which phenobarbital lowers serum bilirubin levels in some patients with jaundice is undefined1–3 although there is some evidence of enhanced synthesis of bilirubin glucuronyl transferase4–7, the hepatic microsomal enzyme which mediates the conjugation of bilirubin before it is excreted into bile. It is also possible, however, that phenobarbital acts by augmenting other excretory pathways involving the degradation of bilirubin to polar breakdown products1–3,8. If phenobarbital enhances the capacity of the liver to conjugate bilirubin, response to drug therapy should be associated with increased excretion of bilirubin into bile. If, on the other hand, phenobarbital augments the other excretory pathways, bile bilirubin should remain unchanged. I have investigated this in male heterozygous and homozygous Gunn rats and Sprague–Dawley rats, weighing 350–500 g.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , and , Amer. J. Med., 45, 160 (1968).

  2. 2.

    , and , Lancet, ii, 73 (1968).

  3. 3.

    , and , J. Clin. Invest., 48, 42 (1969).

  4. 4.

    , and , Amer. J. Dis. Child, 104, 516 (1962).

  5. 5.

    , , , and , New Engl. J. Med., 275, 1461 (1966).

  6. 6.

    , , and , J. Lab. Clin. Med., 70, 273 (1967).

  7. 7.

    , , , , and , Trans. Assoc. Amer. Phys., 181, 66 (1968).

  8. 8.

    , and , J. Clin. Invest., 42, 1720 (1963).

  9. 9.

    , and , Brit. J. Exp. Path., 37, 199 (1956).

  10. 10.

    , and , J. Biol. Chem., 119, 481 (1937).

  11. 11.

    , and , Biochem. Pharm., 16, 827 (1967).

  12. 12.

    , and , Proc. Soc. Exp. Biol. and Med., 94, 461 (1957).

  13. 13.

    , and , Biochem. J., 67, 9P (1957).

  14. 14.

    , , , and , J. Clin. Invest., 37, 1123 (1958).

  15. 15.

    , J. Histochem. Cytochem., 7, 250 (1959).

  16. 16.

    , , and , Amer. J. Physiol., 200, 1091 (1961).

  17. 17.

    , , , and , Nature, 213, 93 (1967).

Download references

Author information

Affiliations

  1. Department of Medicine, Beth Israel Hospital and Harvard Medical School, Boston, Massachusetts 02215.

    • STEPHEN H. ROBINSON

Authors

  1. Search for STEPHEN H. ROBINSON in:

About this article

Publication history

Received

Revised

Published

DOI

https://doi.org/10.1038/222990a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.