Letter | Published:

Angiotensin accelerates Catecholamine Biosynthesis in Sympathetically Innervated Tissues

Naturevolume 222pages987988 (1969) | Download Citation



ANGIOTENSIN interacts with the sympathetic nervous system. Among the interactions which have been described are stimulation of ganglion cells1,3, central activation of the sympathico-adrenal system4,5, and a potentiation of vasoconstrictor responses caused by indirectly acting sympathomimetics6 and by sympathetic nerve stimulation7–9. It is possible that an interaction between the renin-angiotensin and the sympathetic system could play an important part in the development of primary renal hypertension. We have been investigating the effects of circulating polypeptides on sympathetic nerve function, and in particular on the biochemical events involved in the synthesis and release of noradrenaline. Here we report that angiotensin amide-II has a potent stimulating effect on catecholamine biosynthesis in a number of tissues.


  1. 1

    Lewis, G. P., and Reit, E., J. Physiol., 179, 538 (1965).

  2. 2

    Aitken, J. W., and Reit, E., J. Pharmacol Exp. Ther., 159, 107 (1968).

  3. 3

    Farr, W. C., and Grupp, G., J. Pharmacol. Exp. Ther., 156, 528 (1967).

  4. 4

    Bickerton, R. K., and Buckely, J. P., Proc. Soc. Exp. Biol., 106, 834 (1961).

  5. 5

    Scroop, G. C., and Whelan, R. F., Clin. Sci., 30, 79 (1966).

  6. 6

    McCubbin, J. W., and Page, I. H., Circulation Res., 12, 553 (1963).

  7. 7

    Bennelli, G., Della Bella, D., and Gandini, A., Brit. J. Pharmacol Chemother., 22, 211 (1965).

  8. 8

    Zimmerman, B. G., and Gomez, J., Int. J. Neuropharmacol., 4, 185 (1965).

  9. 9

    Zimmerman, B. G., and Gisslen, J., J. Pharmacol Exp. Ther., 163, 320 (1968).

  10. 10

    Roth, R. H., and Stone, E. A., Biochem. Pharmacol., 17, 1581 (1968).

  11. 11

    Roth, R. H., Stjärne, L., and Euler, U. S. von, J. Pharmacol. Exp. Ther., 158, 373 (1967).

  12. 12

    Stjärne, L., and Lishajko, F., Biochem. Pharmacol., 16, 1723 (1967).

  13. 13

    Levitt, M., Spector, S., Sjoerdsma, A., and Udenfriend, S., J. Pharmacol. Exp. Ther., 148, 1 (1965).

  14. 14

    Weiner, N., and Rabadjija, M., J. Pharmacol. Exp. Ther., 160, 61 (1968).

  15. 15

    Kaplan, N. M., and Bartler, F. C., J. Clin. Invest., 41, 715 (1962).

Download references

Author information


  1. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510

    •  & ROBERT H. ROTH


  1. Search for MARGARET C. BOADLE in:

  2. Search for JOHN HUGHES in:

  3. Search for ROBERT H. ROTH in:

About this article

Publication history



Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.