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Substructures in Ribosomes of E. coli ? A Hypothesis for the Attachment of Transfer RNAs

Abstract

RECENT structural models1 for ribosomes give no insight into the interaction between ribosomal components and tRNA and mRNA during translation. We propose a structural model for the E. coli ribosome which does this through substructures, consisting of protein and RNA, which are spatially organized in the 70S ribosome and direct individual tRNAs to a common peptide bond formation site.

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References

  1. Cox, R. A., Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse für Medizin, 1, 23 (1968).

    Google Scholar 

  2. Spencer, M., Pigram, W. J., and Littlechild, J., Biochim. Biophys. Acta (in the press).

  3. Möller, W., Amons, R., Groene, J. C. L., Garrett, R. A., and Terhorst, C. P., Biochim. Biophys. Acta (in the press).

  4. Cotter, R. I., McPhie, P., and Gratzer, W. B., Nature, 216, 864 (1967).

    Article  ADS  CAS  Google Scholar 

  5. Cotter, R. I., and Gratzer, W. B., Nature, 221, 154 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Möller, W., and Chrambach, A., J. Mol. Biol., 23, 377 (1967).

    Article  Google Scholar 

  7. Svedberg, T., and Pedersen, K. O., The Ultracentrifuge, 351 (Oxford University Press, 1940).

    Google Scholar 

  8. Kaltschmidt, E., Dzionara, M., Donner, D., and Wittmann, H. G., in Molecular Genetics (edit. by Wittmann, H. G., and Schuster, H.) (Springer-Verlag, Berlin, New York, 1968).

    Google Scholar 

  9. Delius, H., Traut, R. R., Moore, P. B., Noller, H., and Pearson, P., in Molecular Genetics (edit. by Wittmann, H. G., and Schuster, H.) (Springer-Verlag, Berlin, New York, 1968).

    Google Scholar 

  10. Kurland, C. G., J. Mol. Biol., 2, 83 (1960).

    Article  CAS  Google Scholar 

  11. Bruskov, V. I., and Kiselev, N. A., J. Mol. Biol., 37, 367 (1968).

    Article  CAS  Google Scholar 

  12. Aronson, A. I., and McCarthy, B. J., Biophys. J., 1, 215 (1961).

    Article  CAS  Google Scholar 

  13. Möller, W., and Boedtker, H., Colloque International sur les Acides Ribonucléiques et les Polyphosphates, Strasbourg (1961), 99 (CNRS, Paris, 1962).

    Google Scholar 

  14. Rosset, R., Monier, R., and Julien, J., Bull. Soc. Chim. Biol., 46, 87 (1964).

    CAS  Google Scholar 

  15. Geroch, M. E., Richards, E. G., and Davies, G. A., Europ. J. Biochem., 6, 325 (1968).

    Article  CAS  Google Scholar 

  16. Brownlee, G. G., Sanger, F., and Barrell, B. G., Nature, 215, 735 (1967).

    Article  ADS  CAS  Google Scholar 

  17. Zehavi-Willner, T., and Comb, D. G., J. Mol. Biol., 16, 250 (1966).

    Article  CAS  Google Scholar 

  18. Morrell, P., and Marmur, J., Biochemistry, 7, 1141 (1968).

    Article  Google Scholar 

  19. Arnott, S., Hutchinson, F., Spencer, M., Wilkins, M. H. F., Fuller, W., and Langridge, R. J., Nature, 211, 227 (1966).

    Article  ADS  CAS  Google Scholar 

  20. Goodman, H. M., Abelson, J., Landy, A., Brenner, S., and Smith, J. D., Nature, 217, 1019 (1968).

    Article  ADS  CAS  Google Scholar 

  21. Dube, S. K., Marcker, K. A., Clark, B. F. C., and Cory, S., Nature, 218, 232 (1968).

    Article  ADS  CAS  Google Scholar 

  22. Cory, S., Marcker, K. A., Dube, S. K., and Clark, B. F. C., Nature, 220, 1039 (1968).

    Article  ADS  CAS  Google Scholar 

  23. Holley, R. W., Apgar, J., Everett, G. A., Madison, J. T., Marquisee, M., Merrill, S. H., Penswick, J. R., and Zamir, A., Science, 147, 1462 (1965).

    Article  ADS  CAS  Google Scholar 

  24. Zachau, H. G., Dütting, D., and Feldmann, H. Z., Physiol. Chem., 347, 212 (1966).

    Article  CAS  Google Scholar 

  25. RajBhandary, U. L., Chang, S. H., Stuart, A., Faulkner, R. D., Hoskinson, R. M., and Khorana, H. G., Proc. US Nat. Acad. Sci., 57, 751 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Madison, J. T., Everett, G. A., and Kung, H., Science, 153, 531 (1966).

    Article  ADS  CAS  Google Scholar 

  27. Baev, A. A., Venkstern, T. V., Mirzabekov, A. D., Krutilina, A. I., Li, L., and Axelrod, V. D., Mol. Biol., 1, 754 (1967).

    CAS  Google Scholar 

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MöLLER, W. Substructures in Ribosomes of E. coli ? A Hypothesis for the Attachment of Transfer RNAs. Nature 222, 979–981 (1969). https://doi.org/10.1038/222979a0

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  • DOI: https://doi.org/10.1038/222979a0

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