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Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum


RECENT estimates1,2, based on observations of radio-isotopically labelled cholecalciferol for up to 4 days, suggest that the biological half-life of vitamin D in human plasma does not exceed 50 h. Conversely, after administration of large amounts of vitamin D, the “vitamin D activity” of plasma assayed biologically falls slowly3,4, with a half-time that may exceed 3 months (unpublished work of G. A. L. and S. W. S.).

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MAWER, E., LUMB, G. & STANBURY, S. Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum. Nature 222, 482–483 (1969).

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