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In vitro Synthesis of the Foetal α1-Globulin in Man

Nature volume 222, pages 12961299 (28 June 1969) | Download Citation

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Abstract

DURING the development of the human foetus, the serum proteins differ quantitatively and qualitatively from those present during neonatal life. IgG, the main immunoglobulin, is almost completely of maternal origin, although the foetal spleen starts to synthesize this protein at about the twentieth week of gestation1,2. IgA is usually absent in foetal serum, and its synthesis commences only a few weeks after birth. IgM does not cross the human placenta, but small amounts can be detected in foetal serum; its synthesis also begins at about the twentieth week of foetal life1,2.

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Affiliations

  1. Department of Microbial Diseases, University Hospital, Leiden, Holland.

    • R. VAN FURTH
  2. Paediatric Research Unit, Guy's Hospital Medical School, London SE1.

    • M. ADINOLFI

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https://doi.org/10.1038/2221296a0

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