Letter | Published:

Live and Inactivated Vaccines of Group B Arboviruses: Role of Neutralizing Antibody and Serum Protective Factor

Nature volume 222, pages 12941295 (28 June 1969) | Download Citation

Subjects

Abstract

IT is generally accepted that vaccination provides protection against subsequent viral disease either by stimulating the production of neutralizing antibody or by sensitizing the antibody producing cells so that on infection neutralizing antibody is produced1. The results presented here suggest that inactivated group B arbovirus vaccines depend chiefly on the production of neutralizing antibody to provide protection against subsequent viral disease, whereas live group B arbovirus vaccines depend not only on neutralizing antibody but also on the presence of a new humoral substance which we call serum protective factor (SPF)2 Indeed, using the immunosuppressant drug cyclophosphamide, serum protective factor can be shown to provide protection in the absence of any detectable neutralizing antibody response before the initiation of infection or subsequent to the challenge virus. Thus live group B arbovirus vaccines produce two lines of defence because neutralizing antibody acts on the virus before it penetrates the cell and serum protective factor acts on the cell to confer protection2.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , Viral and Rickettsial Infections of Man (edit. by Horsfall, Jun., F. L., and Tamm, I.), 356 (1965).

  2. 2.

    , and , Amer. J. Epidemiol., 88, 287 (1968).

  3. 3.

    , and , Amer. J. Epidemiol., 84, 193 (1966).

  4. 4.

    , , , and , Amer. J. Epidemiol., 86, 11 (1967).

  5. 5.

    , and , Amer. J. Epidemiol., 89, 593 (1969).

  6. 6.

    , Nature, 175, 581 (1956).

  7. 7.

    , and , Nature, 220, 399 (1968).

  8. 8.

    , and , Amer. J. Epidemiol., 90, 62 (1969).

  9. 9.

    , , and , Amer. J. Hyg., 66, 363 (1957).

Download references

Author information

Affiliations

  1. Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland.

    • W. H. PRICE
    •  & I. S. THIND

Authors

  1. Search for W. H. PRICE in:

  2. Search for I. S. THIND in:

About this article

Publication history

Received

Revised

Published

DOI

https://doi.org/10.1038/2221294a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.