Letter | Published:

Antibody Heterogeneity of Anti-I Cold Agglutinins as shown by Cord Cell Studies

Nature volume 222, pages 12881289 (28 June 1969) | Download Citation

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Abstract

MOST red cell cold agglutinins encountered in clinical practice show anti-I specificity, reacting best with I red cells and weakly or not at all with i (adult) or cord (icord) cells1,2. Because red cells from adults of i status are not generally available, a convenient and commonly used way of determining cold agglutinin specificity is to compare titres obtained with OI and Oicord cells. Here I describe a remarkable heterogeneity in the reactions of anti-I sera and of cord cells from different donors. Such heterogeneity was a feature even of cold agglutinins associated with a single aetiological agent, infection with Mycoplasma pneumoniae.

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References

  1. 1.

    , , , and , Ann. Intern. Med., 221 (1956).

  2. 2.

    , The Haemolytic Anaemias (second ed.), 343, 494 (Churchill, London, 1962).

  3. 3.

    , and , Transfusion (in the press).

  4. 4.

    , , , and , Brit. Med. J., 1, 457 (1967).

  5. 5.

    , Nobel Symposium 3, Gamma Globulins (edit. by Killander, J.), 21 (Interscience, New York, 1967).

  6. 6.

    , and , Clin. Exp. Immunol., 3, 923 (1968).

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Author notes

    • TEN FEIZI

    Pressnt address: The Rockefeller University, 66th Street and York Avenue, New York, New York 10021.

Affiliations

  1. Department of Medicine, Royal Free Hospital, London WC1.

    • TEN FEIZI

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DOI

https://doi.org/10.1038/2221288a0

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