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Chromosome Pattern of Bone Marrow Fibroblasts in Patients with Chronic Granulocytic Leukaemia

Nature volume 222, pages 12781279 (28 June 1969) | Download Citation

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Abstract

GRANULOCYTES, erythroblasts and megakaryocytes from patients with chronic granulocytic leukaemia contain the Ph1 chromosome1–3 in contrast to lymphocytes, which do not3. Skin fibroblasts from at least one case of chronic granulocytic leukaemia did not, however, have the Ph1 chromosome4. Because myelofibrosis occurs in association with chronic granulocytic leukaemia5–7 and because it is also considered to be a myeloproliferative disorder, the question has arisen7 of the presence of a Ph1 chromosome in marrow fibroblasts.

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Affiliations

  1. Blood Research Laboratory, New England Medical Center Hospitals, and Department of Medicine, Tufts University School of Medicine.

    • A. K. MANIATIS
    • , S. AMSEL
    • , W. J. MITUS
    •  & N. COLEMAN

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https://doi.org/10.1038/2221278a0

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