Abstract
THE mule (2n=63) is a hybrid between a jack donkey (Equus asinus, 2n=62) and a mare (E. caballus, 2n=64). The two chromosome complements are quite distinct, and in particular the X chromosomes differ morphologically; the donkey X (XD) is submetacentric and the horse X (XH) is metacentric (Fig. 1). It has also been shown that the glucose-6-phosphate dehydrogenase (G6PD) locus is X-linked in both1,2. The electrophoretic phenotype consists of a fast and slow band in both species, the G6PD of the donkey moving faster than the G6PD of the horse (Fig. 2). If one of the X chromosomes in the female mule is inactivated at random and if this inactivation can be recognized by a delay in its DNA synthesis3–5, then about 50 per cent of cells should show a late replicating XH and 50 per cent a late replicating XD. Furthermore, the G6PD pattern in the mule should consist of three bands, a fast G6PD-donkey, a mixed intermediate band corresponding to the slow G6PD-donkey plus the fast G6PD-horse and finally a slow G6PD-horse (Fig. 2).
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References
Trujillo, J. M., Walden, B., O'Niel, P., and Anstall, H. B., Science, 148, 1603 (1965).
Mathai, C. K., Ohno, S., and Beutler, E., Nature, 210, 115 (1966).
Lyon, M. F., in Advances in Teratology (edit. by Woollam, D. H. M.), 1 (Logos Press, London, 1966).
Evans, H. J., Ford, C. E., Lyon, M. F., and Gray, J., Nature, 206, 900 (1965).
Grumbach, M. M., Morishima, H., and Taylor, J. M., Proc. US Nat. Acad. Sci., 49, 581 (1963).
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A., Exp. Cell Res., 20, 613 (1960).
Harnden, D. G., Brit. J. Exp. Pathol., 41, 31 (1960).
Stubblefield, E., J. Cell Biol., 25, 137 (1965).
Smithies, O., Biochem. J., 71, 385 (1968).
Mukherjee, B. B., and Sinha, A. K., Proc. US Nat. Acad. Sci., 51, 252 (1964).
Castro Sierra, E., and Ohno, S., Biochem. Genet., 1, 323 (1968).
Hitzeroth, H., Klose, J., Ohno, S., and Wolf, U., Biochem. Genet., 1, 287 (1968).
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HAMERTON, J., GIANNELLI, F., COLLINS, F. et al. Non-random X-Inactivation in the Female Mule. Nature 222, 1277–1278 (1969). https://doi.org/10.1038/2221277a0
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DOI: https://doi.org/10.1038/2221277a0
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