Letter | Published:

Amino and Carboxy-terminal Sequences of Ovine Lactogenic Hormone

Nature volume 222, pages 12681269 (28 June 1969) | Download Citation

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Abstract

LACTOGENIC hormone (prolactin) isolated from sheep pituitary glands is a protein of molecular weight1,2 24,000 with threonine at the NH2-terminus3 and half-cystine at the COOH-terminus4. It has six half-cystine and seven methionine residues5. We report here the structure of the NH2-terminal sequence, consisting of twenty-four amino-acids as well as six amino-acid residues at the COOH-terminus of the hormone.

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Author information

Author notes

    • KNUD D. SCHMIDT

    Permanent address: Nordisk Insulinlaboratorium, Department of Biochemistry, 2, Ved Stadion, Gentofte, Denmark.

    • YURI A. PANKOV

    Permanent address: Institute of Endocrinology and Hormone Chemistry of the USSR Academy of Medical Sciences, Moscow.

    • TUNG-BIN LO

    On leave from Department of Chemistry, National Taiwan University, Formosa.

Affiliations

  1. Hormone Research Laboratory, University of California, San Francisco, California.

    • CHOH HAO LI
    • , JONATHAN S. DIXON
    • , KNUD D. SCHMIDT
    • , YURI A. PANKOV
    •  & TUNG-BIN LO

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https://doi.org/10.1038/2221268a0

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