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Identification of Residues responsible for the Alkaline Bohr Effect in Haemoglobin

Nature volume 222, pages 12401243 (28 June 1969) | Download Citation

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Abstract

The imidazole groups of the C-terminal histidines of the β-chains, together with the α-amino groups of the α-chains, are responsible for most of the Bohr effect. In oxyhaemoglobin these groups are free, while in deoxyhaemoglobin their pKs are raised, probably by linkage to carboxyl groups.

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References

  1. 1.

    , Adv. Protein Chem., 4, 407 (1948).

  2. 2.

    , and , Symp. on CO2 (International Union of Physiological Sciences, 1968) (in the press).

  3. 3.

    , and , following article, Nature, 222, 1243 (1969).

  4. 4.

    , J. Biol. Chem., 236, 1948 (1961).

  5. 5.

    , and , J. Biol. Chem., 236, 405 (1961).

  6. 6.

    , , and , J. Gen. Physiol., 44, 889 (1961).

  7. 7.

    , and , Biochemistry, 1, 735 (1962).

  8. 8.

    , , , and , Proc. US Nat. Acad. Sci., 48, 1057 (1962).

  9. 9.

    , , , and , J. Biol. Chem., 241, 241 (1966).

  10. 10.

    , J. Crystal Growth, 2, 54 (1968).

  11. 11.

    , , , and , J. Mol. Biol., 28, 117 (1967).

  12. 12.

    , , and , J. Mol. Biol., 33, 283 (1968).

  13. 13.

    , , , , , , and , Nature, 219, 29 (1968).

  14. 14.

    , and , Nature, 219, 902 (1968).

  15. 15.

    , J. Biol. Chem., 242, 3672 (1967).

  16. 16.

    , Physiol. Rev., 45, 123 (1965).

  17. 17.

    , and , Proc. US Nat. Acad. Sci., 58, 19 (1967).

  18. 18.

    , and , J. Biol. Chem., 244, No. 12 (1969).

  19. 19.

    , , , , and , J. Biol. Chem., 236, PC60 (1961).

  20. 20.

    , , and , J. Biol. Chem., 239, 1804 (1964).

  21. 21.

    , J. Biol. Chem., 242, 3685 (1967).

  22. 22.

    , and , Atlas of Protein Sequence and Structure (National Biomedical Research Foundation, Silver Spring, 1967–68).

  23. 23.

    , J. Biol. Chem., 242, 3685 (1967).

  24. 24.

    , and (in the press).

  25. 25.

    , and , in The Proteins (edit. by Neurath, H.), 139 (Academic Press, New York, 1964).

  26. 26.

    , , , and , J. Biol. Chem., 240, PC 2262 (1965).

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Author notes

    • L. MAZZARELLA

    Now at Istituto Chimico, Naples, Italy.

Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge

    • M. F. PERUTZ
    • , HILARY MUIRHEAD
    • , L. MAZZARELLA
    • , R. A. CROWTHER
    • , J. GREER
    •  & J. V. KILMARTIN  

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https://doi.org/10.1038/2221240a0

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