Immunoglobulin Synthesis in Hereditarily Spleenless Mice

Abstract

RENEWED interest in the requirement of the spleen for immunological competence1ndash;4 has stimulated us to investigate its need to produce various antibodies. So far genetically spleenless mice5 have been used in only one immunological study that revealed their capacity to produce antibody to bacteria6. Differentiation of antibodies that agglutinate from those that lyse erythrocytes7–9 as well as delineation of two varieties of skin-sensitizing immunoglobulins in mice10 has enabled us to search for these in hereditarily spleenless mice (B6.CBA, Dh/+), their normal littermates (B6.CBA, +/+) and +/+ littermates splenectomized as adults (made available by Dr M. C. Green, The Jackson Laboratory, Bar Harbor, Maine).

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BATTISTO, J., CANTOR, L., BOREK, F. et al. Immunoglobulin Synthesis in Hereditarily Spleenless Mice. Nature 222, 1196–1198 (1969). https://doi.org/10.1038/2221196a0

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