Letter | Published:

Persistence of Antigen on the Surface of Macrophages

Nature volume 222, pages 11931195 (21 June 1969) | Download Citation

Subjects

Abstract

MOUSE peritoneal macrophages can take up and catabolize two different haemocyanins1,2. Although in tissue culture experiments most of these materials were broken down in a few hours after uptake, haemocyanin nevertheless elicited the formation of specific antibodies when the macrophages were transferred to syngeneic hosts, and the haemocyanin bound to macrophages retained its immunogenic activity relatively unchanged for several days. In view of the observation that a small percentage of the haemocyanin bound to macrophages remained intact during in vitro culture for 72 h, we undertook the experiments described here to determine the localization of the persisting antigen (which would presumably comprise the immunogenic moiety).

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , J. Exp. Med., 127, 915 (1968).

  2. 2.

    , J. Immunol. (in the press).

  3. 3.

    , and , Int. Arch. Allergy, 29, 185 (1966).

  4. 4.

    , , and , J. Exp. Med., 127, 277 (1968).

  5. 5.

    , and , Life Sci., 3, 1407 (1964).

  6. 6.

    , , and , J. Immunol. (in the press).

  7. 7.

    , and , J. Exp. Med., 123, 119 (1966).

  8. 8.

    , and , J. Exp. Med., 126, 941 (1967).

  9. 9.

    , , and , J. Exp. Med., 127, 1003 (1968).

  10. 10.

    , , , and , Arch. Biochem. Biophys., 116, 82 (1966).

  11. 11.

    , and , Tex. Ref. Biol. Med., 20, 683 (1962).

  12. 12.

    , , and , J. Exp. Med., 125, 1119 (1967).

Download references

Author information

Affiliations

  1. Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

    • E. R. UNANUE
    •  & J.-C. CEROTTINI
  2. Clinical Research Centre, Mill Hill, London.

    • MAUREEN BEDFORD

Authors

  1. Search for E. R. UNANUE in:

  2. Search for J.-C. CEROTTINI in:

  3. Search for MAUREEN BEDFORD in:

About this article

Publication history

Received

Published

DOI

https://doi.org/10.1038/2221193a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.