Letter | Published:

In vitro Production of Angiotensin I by Renal Glomeruli

Naturevolume 222pages11861188 (1969) | Download Citation

Subjects

Abstract

To investigate the mechanism of the release of renin we have isolated the juxtaglomerular apparatus and recorded changes in renin secretion in response to various stimuli. To separate and concentrate the juxtaglomerular apparatus we isolated glomeruli and incubated them in a defined medium. The glomeruli were then tested for pressor activity. Clearly, if such a preparation had a characteristic secretion pattern for renin, then we would have a concentration of viable juxtaglomerular apparatus ready for in vitro studies. This communication summarizes our results and the unexpected finding that glomeruli produce a pressor substance distinct from renin.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Biol. Chem., 193, 265 (1961).

  2. 2

    Arakawa, K., and Nakamura, M., Circulation Res., 21 (Suppl. II), 101 (1968).

  3. 3

    Bumpus, F. M., Trans. NY Acad. Sci., 27, 445 (1965).

  4. 4

    Skeggs, L. T., Kahn, J. R., and Shumway, N. P., J. Exp. Med., 103, 295 (1956).

  5. 5

    Martin, E., Scheideger, J. J., Grabar, P., and Williams, C. A., Bull. Schwiz. Akad. Med. Wiss., 10, 193 (1954).

Download references

Author information

Affiliations

  1. Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    • SAMUEL FINKIELMAN
    •  & VICTOR E. NAHMOD

Authors

  1. Search for SAMUEL FINKIELMAN in:

  2. Search for VICTOR E. NAHMOD in:

About this article

Publication history

Received

Revised

Issue Date

DOI

https://doi.org/10.1038/2221186a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.