Abstract
To investigate the mechanism of the release of renin we have isolated the juxtaglomerular apparatus and recorded changes in renin secretion in response to various stimuli. To separate and concentrate the juxtaglomerular apparatus we isolated glomeruli and incubated them in a defined medium. The glomeruli were then tested for pressor activity. Clearly, if such a preparation had a characteristic secretion pattern for renin, then we would have a concentration of viable juxtaglomerular apparatus ready for in vitro studies. This communication summarizes our results and the unexpected finding that glomeruli produce a pressor substance distinct from renin.
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FINKIELMAN, S., NAHMOD, V. In vitro Production of Angiotensin I by Renal Glomeruli. Nature 222, 1186–1188 (1969). https://doi.org/10.1038/2221186a0
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DOI: https://doi.org/10.1038/2221186a0
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