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Synthetic Double-stranded RNA: Inhibitory Effect on Murine Leukaemia and Sarcoma Viruses in Cell Cultures

Nature volume 222, pages 11661168 (21 June 1969) | Download Citation

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Abstract

THE synthetic double-stranded RNA, polyinosinic : polycytidilic acid (poly I : poly C) exerts its antiviral action by stimulating the production in vitro and in vivo of interferon1–6. Sarma et al.7 found recently that poly I : poly C has a similar inhibitory effect on mouse sarcoma virus (MSV) infection in vivo7 and in vitro (personal communication, P. S. Sarma et al.). We have confirmed the inhibitory effect of poly I : poly C on cellular transformation induced by MSV, and studied its optimal conditions. We also describe the inhibitory effect of poly I : poly C on the growth of Friend leukaemia virus in mouse embryo cells.

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Author information

Affiliations

  1. Microbiological Associates, Inc., and National Institutes of Health, Bethesda, Maryland.

    • JOHNG S. RHIM
    • , CHARLOTTE GKEENAWALT
    •  & ROBERT J. HUEBNER

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https://doi.org/10.1038/2221166a0

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