Article | Published:

Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides

Nature volume 222, pages 11481152 (21 June 1969) | Download Citation

Subjects

Abstract

Several polyribonucleotides, both as single species and when annealed in pairs, are able to induce interferon production in mammalian cells and cellular resistance to virus infection. These studies suggest that a stable secondary, presumably multistranded structure is required for this activity.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , , , and , Proc. US Nat. Acad. Sci., 58, 1004 (1967).

  2. 2.

    , , , and , J. Virol., 2, 648 (1968).

  3. 3.

    , and , Interferon Scientific Memorandum, No. 59 (April, 1968).

  4. 4.

    , , , , and , Interferon Scientific Memorandum, No. 81 (May, 1968).

  5. 5.

    , , , and , Proc. US Nat. Acad. Sci., 61, 340 (1968).

  6. 6.

    , , , , and , Japan J. Microbiol., 12, 329 (1968).

  7. 7.

    , , , , and , Interferon Scientific Memorandum, No. 55 (March, 1968).

  8. 8.

    , , , and , Interferon Scientific Memorandum, No. 90 (June, 1968).

  9. 9.

    , , and , Science, 161, 465 (1968).

  10. 10.

    , and , in Methods of Biochemical Analysis (edit. by Glick, D.), 1, 304 (Interscience, New York, 1954).

  11. 11.

    , , and , in The Nucleic Acids (edit. by Chargaff, E., and Davidson, J. N.), 1, 493 (Academic Press, New York, 1955).

  12. 12.

    , , , , and , Proc. US Nat. Acad. Sci., 45, 482 (1959).

  13. 13.

    , and , Biochim. Biophys. Acta, 114, 469 (1966).

  14. 14.

    , Fed. Proc., 24, 1446 (1965).

  15. 15.

    , and , Biochim. Biophys. Acta, 129, 460 (1966).

  16. 16.

    , , and , Biochim. Biophys. Acta, 55, 584 (1962).

  17. 17.

    , and , Biochim. Biophys. Acta, 7, 396 (1951).

  18. 18.

    , , and , Biochemistry, 3, 1015 (1964).

  19. 19.

    , , and , in Progress in Nucleic Acid Research and Molecular Biology (edit. by Davidson, J. N., and Cohn, W. E.), 6, 83 (Academic Press, New York, 1967).

  20. 20.

    , , and , Biopolymers, 1, 431 (1963).

  21. 21.

    , Proc. US Nat. Acad. Sci., 46, 445 (1960).

  22. 22.

    , and , J. Biol. Chem., 240, 2088 (1965).

  23. 23.

    , J. Amer. Chem. Soc., 85, 3298 (1963).

  24. 24.

    , and , Biochemistry, 4, 1238 (1965).

  25. 25.

    , and , J. Amer. Chem. Soc., 79, 3928 (1957).

  26. 26.

    , and , Ann. NY Acad. Sci., 81, 730 (1959).

  27. 27.

    , Nature, 202, 797 (1964).

  28. 28.

    , , , and , J. Mol. Biol., 10, 28 (1964).

  29. 29.

    , and , J. Mol. Biol., 11, 620 (1965); , , and , J. Mol. Biol., 12, 726 (1965); , and , Biopolymers, 3, 121 (1965).

  30. 30.

    , and , J. Mol. Biol., 15, 455 (1966).

  31. 31.

    , , and , J. Mol. Biol., 15, 467 (1966).

  32. 32.

    , , , and , J. Mol. Biol., 3, 71 (1961); , and , Biochim. Biophys. Acta, 55, 601 (1962); , , and , Biochemistry, 2, 340 (1963); , and , Nature, 198, 725 (1963); , and , J. Amer. Chem. Soc., 87, 2033 (1965).

  33. 33.

    , , , and , Arch. Biochem. Biophys., 62, 253 (1956).

  34. 34.

    , and , J. Biol. Chem., 236, 2738 (1961).

  35. 35.

    , J. Biochem. (Japan), 51, 95 (1962).

  36. 36.

    , , , , and , Proc. US Nat. Acad. Sci., 58, 782 (1967).

  37. 37.

    , , , and , Proc. US Nat. Acad. Sci., 58, 1719 (1967).

  38. 38.

    , , , , and , Proc. US Nat. Acad. Sci., 58, 2102 (1967).

  39. 39.

    , and , Polynucleotides (Elsevier, Amsterdam, 1961).

  40. 40.

    , and , Proc. US Nat. Acad. Sci., 56, 1528 (1966).

  41. 41.

    , and , J. Mol. Biol., 12, 410 (1965).

  42. 42.

    , , and , J. Amer. Chem. Soc., 79, 2023 (1957). , and , Bichim. Biophys. Acta, 26, 457 (1957). , , and , J. Mol. Biol., 30, 291 (1967).

  43. 43.

    , and , Proc. US Nat. Acad. Sci., 53, 1425 (1965).

  44. 44.

    , and , Biochemistry, 7, 7 (1968).

  45. 45.

    , and , Nature, 212, 1309 (1966).

  46. 46.

    , Biochim. Biophys. Acta, 29, 502 (1958).

  47. 47.

    , , and , Biochim. Biophys. Acta, 123, 221 (1966).

  48. 48.

    , and , Proc. US Nat. Acad. Sci. (in the press).

  49. 49.

    , Interferon Scientific Memorandum, No. 143 (January, 1969).

Download references

Author information

Author notes

    • E. DE CLERCQ

    Lilly International Fellow, aspirant of the Belgian N.F.W.O. (Nationaal Fonds voor Wetenschappelijk Onderzoek).

Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California

    • E. DE CLERCQ
    •  & T. C. MERIGAN

Authors

  1. Search for E. DE CLERCQ in:

  2. Search for T. C. MERIGAN in:

About this article

Publication history

Received

Revised

Published

DOI

https://doi.org/10.1038/2221148a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.