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Improved Graft Survival after Treatment with Bordetella and Anti-lymphocyte Serum

Nature volume 222, pages 10831085 (14 June 1969) | Download Citation

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Abstract

Bordetella pertussis increases the number of circulating lymphocytes1 and alters their migratory behaviour2, which suggests that mice treated with B. pertussis may be particularly susceptible to the immunosuppressive effect of anti-lymphocyte serum (ALS). Here we report that combined treatment with B. pertussis and ALS causes skin grafts to survive longer, in spite of a strong histocompatibility barrier, than treatment with either alone.

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References

  1. 1.

    , J. Exp. Med., 121, 49 (1965).

  2. 2.

    , and , J. Exp. Med., 125, 619 (1967).

  3. 3.

    , and , Proc. US Nat. Acad. Sci., 56, 1130 (1966).

  4. 4.

    , , and , Nature, 217, 177 (1968).

  5. 5.

    , and , Immunol., 15, 405 (1968).

  6. 6.

    , Int. Arch. All., 26, 340 (1965).

  7. 7.

    , Nature, 216, 1235 (1967).

  8. 8.

    , and , in Biological Basis of Medical Practice, 4, 327 (Academic Press, London , and New York, 1969).

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Author information

Affiliations

  1. Department of Medical Microbiology, Medical Academy, Cracow, Poland.

    • W. PTAK
  2. London Hospital Medical College, Tarner Street, London E1.

    • H. FESTENSTEIN
    •  & G. L. ASHERSON
  3. Division of Immunology, Clinical Research Centre, Northwick Park, Middlesex.

    • A. M. DENMAN

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DOI

https://doi.org/10.1038/2221083a0

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