Abstract
Bordetella pertussis increases the number of circulating lymphocytes1 and alters their migratory behaviour2, which suggests that mice treated with B. pertussis may be particularly susceptible to the immunosuppressive effect of anti-lymphocyte serum (ALS). Here we report that combined treatment with B. pertussis and ALS causes skin grafts to survive longer, in spite of a strong histocompatibility barrier, than treatment with either alone.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Morse, S. I., J. Exp. Med., 121, 49 (1965).
Morse, S. I., and Riester, S. K., J. Exp. Med., 125, 619 (1967).
Levey, R. H., and Medawar, P. B., Proc. US Nat. Acad. Sci., 56, 1130 (1966).
Denman, A. M., Denman, E. J., and Holborow, E. J., Nature, 217, 177 (1968).
Asherson, G. L., and Ptak, W., Immunol., 15, 405 (1968).
Floersheim, G. L., Int. Arch. All., 26, 340 (1965).
Floersheim, G. L., Nature, 216, 1235 (1967).
Asherson, G. L., and Allwood, G. G., in Biological Basis of Medical Practice, 4, 327 (Academic Press, London, and New York, 1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PTAK, W., FESTENSTEIN, H., ASHERSON, G. et al. Improved Graft Survival after Treatment with Bordetella and Anti-lymphocyte Serum. Nature 222, 1083–1085 (1969). https://doi.org/10.1038/2221083a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2221083a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.