Letter | Published:

Triallelic Complementation and the Subunit Structure of Enzymes

Nature volume 222, pages 10781079 (14 June 1969) | Download Citation

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Abstract

INTERALLELIC complementation makes a genetical approach to the problem of enzyme structure possible. It is expressed as the partial to complete restoration of the normal phenotype in heterocaryons or heterozygotes derived from different allelic mutants. Detection of complementation between alleles of any specific gene suggests that such a gene controls an enzyme with quaternary structure. Moreover, this effect shows that the enzyme contains identical subunits.

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Affiliations

  1. Department of Genetics and Selection, Leningrad State University, Leningrad, USSR.

    • S. G. INGE-VECHTOMOV
    •  & V. V. PAVLENKO

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DOI

https://doi.org/10.1038/2221078a0

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