Abstract
NEURONES of the insect central nervous system have proved to be relatively insensitive to applied acetylcholine1–5. The threshold to acetylcholine applied to the nerve cord ranged from 10−2 M to 10−5 M. An explanation of this is that there is a high concentration of choline esterase around the nerve cell which effectively reduces the concentration of acetylcholine at the neurone surface to considerably below that applied to the whole central nerve cord6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Roeder, K. D., Bull. Johns Hopkins Hosp., 83, 587 (1948).
Twarog, B., and Roeder, K. D., Ann. Ent. Soc. Amer., 50, 231 (1957).
Yamasaki, T., and Narahashi, T., Nature, 182, 1805 (1958).
Colhoun, E. H., Adv. Insect. Physiol., 1, 1 (1963).
Callec, J., and Boistel, J., CR Soc. Biol., 161, 442 (1967).
Treherne, J. E., and Smith, D. S., J. Exp. Biol., 43, 13 (1965).
Hagiwara, S., and Watanabe, A., J. Cell. Comp. Physiol., 47, 514 (1956).
Callec, J., and Boistel, J., CR Soc. Biol., 160, 1943 (1966).
Rowe, E. C., thesis, Univ. Michigan (1964).
Kerkut, G. A., Pitman, R. M., and Walker, R. J., Life Sci., 7 (1) 605 (1968).
Takeuchi, A., and Takeuchi, N., J. Physiol., 170, 296 (1965).
Gerschenfeld, A., and Stefani, E., J. Physiol., 185, 668 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KERKUT, G., PITMAN, R. & WALKER, R. Sensitivity of Neurones of the Insect Central Nervous System to Iontophoretically Applied Acetylcholine or GABA. Nature 222, 1075–1076 (1969). https://doi.org/10.1038/2221075b0
Received:
Issue Date:
DOI: https://doi.org/10.1038/2221075b0
This article is cited by
-
The distribution of GABA-like immunoreactivity in the thoracic nervous system of the locust Schistocerca gregaria
Cell and Tissue Research (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.