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Sensitivity of Neurones of the Insect Central Nervous System to Iontophoretically Applied Acetylcholine or GABA

Nature volume 222, pages 10751076 (14 June 1969) | Download Citation

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Abstract

NEURONES of the insect central nervous system have proved to be relatively insensitive to applied acetylcholine1–5. The threshold to acetylcholine applied to the nerve cord ranged from 10−2 M to 10−5 M. An explanation of this is that there is a high concentration of choline esterase around the nerve cell which effectively reduces the concentration of acetylcholine at the neurone surface to considerably below that applied to the whole central nerve cord6.

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Affiliations

  1. Department of Physiology and Biochemistry, University of Southampton.

    • G. A. KERKUT
    • , R. M. PITMAN
    •  & R. J. WALKER

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https://doi.org/10.1038/2221075b0

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