Letter | Published:

2-Methylthioadenosine-5′-phosphate: a Specific Inhibitor of Platelet Aggregation

Nature volume 222, pages 10731074 (14 June 1969) | Download Citation

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Abstract

CERTAIN analogues of adenosine have been found to act both in vivo as vasodilators and in vitro as inhibitors of ADP-mediated platelet aggregation, and Born et al.1 suggested that this dual activity may preclude the potential usefulness of adenosine analogues as antithrombotic agents. Work in this institute with 2-substituted adenosine analogues showed that, although they have both vasodilatory and platelet aggregation inhibitory properties, some analogues, for example, 2-methoxyadenosine and 2-trifluoromethyladenosine, were considerably less potent as inhibitors of platelet aggregation than as vasodilators (Table 1). These observations suggested that it may be possible in suitable analogues to separate the two effects. 2-Methylthioadenosine-5′-phosphate (patent application filed) was found to be a potent inhibitor of ADP-mediated platelet aggregation but to have no discernible effects on the cardiovascular system.

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Author information

Affiliations

  1. Smith Kline and French Research Institute, Department of Pharmacology, University of Sydney, Sydney 2006, Australia.

    • FRANK MICHAL
    • , M. HELEN MAGUIRE
    •  & G. GOUGH

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DOI

https://doi.org/10.1038/2221073a0

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