Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

2-Methylthioadenosine-5′-phosphate: a Specific Inhibitor of Platelet Aggregation

Abstract

CERTAIN analogues of adenosine have been found to act both in vivo as vasodilators and in vitro as inhibitors of ADP-mediated platelet aggregation, and Born et al.1 suggested that this dual activity may preclude the potential usefulness of adenosine analogues as antithrombotic agents. Work in this institute with 2-substituted adenosine analogues showed that, although they have both vasodilatory and platelet aggregation inhibitory properties, some analogues, for example, 2-methoxyadenosine and 2-trifluoromethyladenosine, were considerably less potent as inhibitors of platelet aggregation than as vasodilators (Table 1). These observations suggested that it may be possible in suitable analogues to separate the two effects. 2-Methylthioadenosine-5′-phosphate (patent application filed) was found to be a potent inhibitor of ADP-mediated platelet aggregation but to have no discernible effects on the cardiovascular system.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Born, G. V. R., Haslam, R. J., Goldman, M., and Rowe, R. D., Nature, 205, 678 (1965).

    Article  ADS  CAS  Google Scholar 

  2. Tener, G. M., J. Amer. Chem. Soc., 83, 159 (1961).

    Article  CAS  Google Scholar 

  3. Maguire, M. H., and Michal, F., Nature, 217, 571 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Gough, G., Maguire, M. H., and Michal, F., J. Med. Chem. (in the press).

  5. Clayton, S., Born, G. V. R., and Cross, M. J., Nature, 200, 138 (1963).

    Article  ADS  CAS  Google Scholar 

  6. Schaeffer, H. J., and Thomas, H. J., J. Amer. Chem. Soc., 80, 3738 (1958).

    Article  CAS  Google Scholar 

  7. Gough, G., and Maguire, M. H., J. Med. Chem., 8, 866 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

MICHAL, F., MAGUIRE, M. & GOUGH, G. 2-Methylthioadenosine-5′-phosphate: a Specific Inhibitor of Platelet Aggregation. Nature 222, 1073–1074 (1969). https://doi.org/10.1038/2221073a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2221073a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing