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Aldolase C in Brain Tumour

Nature volume 222, page 1070 (14 June 1969) | Download Citation

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Abstract

THREE molecular species of aldolase have been observed in mammalian tissues: aldolase A in muscle, aldolase B in liver and aldolase C in brain1–3. We have already reported that the aldolase B found in the normal rat liver disappeared in the fast growing and highly malignant rat hepatomas and, instead, aldolase A was produced. In slowly growing rat hepatomas, aldolase A, aldolase B and their hybrids were observed4. The existence of aldolase C in the brain attracted our attention and led us to investigate the aldolase isozyme patterns of human brain tumours.

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References

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    , , and , Proc. US Nat. Acad. Sci., 56, 1275 (1966).

  2. 2.

    , , , and , H.–S. Z. Phys. Chem., 348, 1001 (1967).

  3. 3.

    , Biochim. Biophys. Acta, 167, 161 (1968).

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    , , , and , Biochem. Biophys. Res. Commun., 30, 565 (1968).

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    , Cytology and Cellular Pathology of the Nervous System (edit. by Penfield, W.), 905 (Hoeber, New York, 1932).

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Affiliations

  1. Biochemistry Division, National Cancer Center Research Institute.

    • TAKASHI SUGIMURA
    • , SHIGEAKI SATO
    • , SUMIE KAWABE
    •  & NORIO SUZUKI
  2. Neurosurgical Division, National Cancer Center Hospital, Tsukiji, Chuo-ku, Tokyo, Japan.

    • TE CHEN CHIEN
    •  & KINTOMO TAKAKURA

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https://doi.org/10.1038/2221070a0

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