Letter | Published:

Protection by some Carbamates against the Delayed Neurotoxic Effects of Di-isopropyl Phosphorofluoridate

Naturevolume 222pages10661067 (1969) | Download Citation



ADMINISTRATION of a single dose of many organophosphorus esters to hens and other species produces a delayed neurotoxic effect characterized by a flaccid paralysis of hind limbs developing after a symptomless period of 8–14 days (for a review see ref. 1). We have studied the effect produced by di-isopropyl phosphorofluoridate (DFP) because it is a potent neurotoxic compound and does not need to be metabolized to produce the active agent.

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  1. 1

    Aldridge, W. N., and Barnes, J. M., Proc. Europ. Soc. Study of Drug Toxicity, 8, 162; Excerpta Med. Int. Cong., Series No. 118 (1966).

  2. 2

    Johnson, M. K., Abst. First Int. Meet. Int. Soc. Neurochem., Strasbough, 111 (1967).

  3. 3

    Johnson, M. K., Biochem. J., 111, 487 (1969).

  4. 4

    Johnson, M. K., Biochem. J., 110, 13P (1968).

  5. 5

    Johnson, M. K., Biochem. J. (in the press).

  6. 6

    see, for instance, Reiner, E., and Aldridge, W. N., Biochem. J., 105, 171 (1967).

  7. 7

    O'Brien, R. D., Toxic Phosphorus Esters, 100 (Academic Press, New York, 1960).

  8. 8

    Koster, R., J. Pharmacol. Exp. Therap., 88, 39 (1946).

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  1. R. LAUWERYS: Visiting worker from the University of Louvain, Belgium.


  1. Biochemical Mechanisms Section, MRC Toxicology Research Unit, Woodmansterne Road, Carshalton, Surrey

    • M. K. JOHNSON
    •  & R. LAUWERYS


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