Abstract
ADMINISTRATION of a single dose of many organophosphorus esters to hens and other species produces a delayed neurotoxic effect characterized by a flaccid paralysis of hind limbs developing after a symptomless period of 8–14 days (for a review see ref. 1). We have studied the effect produced by di-isopropyl phosphorofluoridate (DFP) because it is a potent neurotoxic compound and does not need to be metabolized to produce the active agent.
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References
Aldridge, W. N., and Barnes, J. M., Proc. Europ. Soc. Study of Drug Toxicity, 8, 162; Excerpta Med. Int. Cong., Series No. 118 (1966).
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see, for instance, Reiner, E., and Aldridge, W. N., Biochem. J., 105, 171 (1967).
O'Brien, R. D., Toxic Phosphorus Esters, 100 (Academic Press, New York, 1960).
Koster, R., J. Pharmacol. Exp. Therap., 88, 39 (1946).
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JOHNSON, M., LAUWERYS, R. Protection by some Carbamates against the Delayed Neurotoxic Effects of Di-isopropyl Phosphorofluoridate. Nature 222, 1066–1067 (1969). https://doi.org/10.1038/2221066a0
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DOI: https://doi.org/10.1038/2221066a0
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