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Uterine, Vaginal and Mammary Tumours induced by Nitrosoureas in Pregnant Rats

Nature volume 222, pages 1064–1065 (1969)Cite this article

Abstract

A NUMBER of nitroso compounds have high carcinogenic activity. Some of them selectively induce tumours at various sites such as the alimentary tract, respiratory, nervous and urinary systems1,2. The influence of changes in the general condition of the organism as well as in the functional activity of specific organs on the pattern of carcinogenesis is virtually unexplored. We report here on a peculiar shift in the organotropic carcinogenic effect of two alkylnitrosoureas in pregnant rats observed during 80 weeks after treatment.

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Authors and Affiliations

  1. Laboratory of Experimental Tumours, Research Institute of Oncology of the Ministry of Public Health, Leningrad, USSR

    V. A. ALEXANDROV

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  1. V. A. ALEXANDROV
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ALEXANDROV, V. Uterine, Vaginal and Mammary Tumours induced by Nitrosoureas in Pregnant Rats. Nature 222, 1064–1065 (1969). https://doi.org/10.1038/2221064a0

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