Letter | Published:

Uterine, Vaginal and Mammary Tumours induced by Nitrosoureas in Pregnant Rats

Nature volume 222, pages 10641065 (14 June 1969) | Download Citation

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Abstract

A NUMBER of nitroso compounds have high carcinogenic activity. Some of them selectively induce tumours at various sites such as the alimentary tract, respiratory, nervous and urinary systems1,2. The influence of changes in the general condition of the organism as well as in the functional activity of specific organs on the pattern of carcinogenesis is virtually unexplored. We report here on a peculiar shift in the organotropic carcinogenic effect of two alkylnitrosoureas in pregnant rats observed during 80 weeks after treatment.

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References

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Affiliations

  1. Laboratory of Experimental Tumours, Research Institute of Oncology of the Ministry of Public Health, Leningrad, USSR.

    • V. A. ALEXANDROV

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DOI

https://doi.org/10.1038/2221064a0

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