Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Radiation Sensitivity of Rodent Species

Abstract

WILD species of rodents are reported to be more resistant to acute radiation exposure than laboratory strains1. The LD50(30) acute exposure dose for the old-field mouse (Peromyscus polionotus), the cotton mouse (Peromyscus gossypinus) and the harvest mouse (Reithrodontomys humilis) is 1,100 to 1,200 r., for the cotton rat (Sigmodon hispidus) 1,200 to 1,500 r. and for pocket mice (Perognathus formosus and P. longimembris) 1,300 to 1,500 r.2–4. LD50(30) values for laboratory rodents range from 450 to 850 r. when the radiation is delivered as a single acute dose5. Ecologists have tended to interpret this as an advantage conferred by the “wild” condition. Chronic exposure over a long time is, however, less damaging than the same dose given in a short time5, but new results show that wild mice are quite sensitive to damage from chronic exposure in terms of life shortening and reduced fertility.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Chang, M. C., Hunt, D. M., and Turbyfill, C., Nature, 203, 536 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Provost, E. E., and Kellogg, F. E., in Appendix to Annual Report to the AEC, Contract AT(38–1)–310, Task III (1964).

    Google Scholar 

  3. Gambino, J. J., and Lindberg, R. G., Radiat. Res., 22, 586 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Golley, F. B., Gentry, J. B., Menhinick, E. F., and Carmon, J. L., Radiat. Res., 24, 350 (1965).

    Article  ADS  CAS  Google Scholar 

  5. Bond, V. P., Fliedner, T. M., and Archambeau, J. O., Mammalian Radiation Lethality (Academic Press, New York, 1965).

    Google Scholar 

  6. French, N. R., Maza, B. G., and Aschwanden, A. P., Science, 154, 1194 (1966).

    Article  ADS  CAS  Google Scholar 

  7. Andrewartha, H. G., and Birch, L. C., The Distribution and Abundance of Animals (University of Chicago Press, Chicago, 1954).

    Google Scholar 

  8. French, N. R., Health Physics, 11, 1557 (1965).

    Article  CAS  Google Scholar 

  9. Sacher, G. A., and Grahn, D., J. Nat. Cancer Inst., 32, 277 (1964).

    PubMed  CAS  Google Scholar 

  10. Sugahara, T., Genetics, 50, 1143 (1964).

    PubMed Central  Google Scholar 

  11. Searle, A. G., Genetics, 50, 1159 (1964).

    PubMed Central  Google Scholar 

  12. Sacher, G. A., and Trucco, E., in Biological Aspects of Aging (edit. by Shock, N. W.), 244 (Columbia University Press, New York, 1962).

    Google Scholar 

  13. Gambino, J. J., Lindberg, R. G., Hayden, P., and Tagami, T. Y., in Investigations of Perognathus as an Experimental Organism in Space Biology (edit. by Lindberg, R. G.), 240 (Northrop Corporate Laboratories, Hawthorne, California, 1968).

    Google Scholar 

  14. Cosgrove, G. E., Upton, A. C., Congdon, C. C., Dogherty, D. G., Christenberry, K. W., and Gosslee, D. G., Radiat. Res., 21, 550 (1964).

    Article  ADS  CAS  Google Scholar 

  15. Dunmier, W. W., Ecology, 41, 174 (1960).

    Article  Google Scholar 

  16. Marshall, J. S., Ecology, 47, 561 (1966).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

FRENCH, N. Radiation Sensitivity of Rodent Species. Nature 222, 1003–1004 (1969). https://doi.org/10.1038/2221003a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2221003a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing