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On the Molecular Structure of Collagen


Several polytripeptide and polyhexapeptide models of collagen have the same triple helical conformation with one NH…O interchain H bond per tripeptide. Collagen itself probably has this structure.

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  1. Ramachandran, G. N., and Kartha, G., Nature, 176, 593 (1955).

    Article  ADS  CAS  Google Scholar 

  2. Ramachandran, G. N., and Sasisekharan, V., Biochim. Biophys. Acta, 109, 314 (1965).

    Article  CAS  Google Scholar 

  3. Rich, A., and Crick, F. H. C., J. Mol. Biol., 3, 483 (1961).

    Article  CAS  Google Scholar 

  4. Cowan, P. M., McGavin, S., and North, A. C. T., Nature, 176, 1062 (1955).

    Article  ADS  CAS  Google Scholar 

  5. Ramachandran, G., and Chandrasekharan, R., Biopolymers, 6, 1649 (1968).

    Article  CAS  Google Scholar 

  6. Andreeva, N. S., Esipova, N. G., Millionova, M. I., Rogulenkova, V. N., and Shibnev, V. A., Conformation of Biopolymers, 2, 469 (edit. by Ramachandran, G. N.) (Academic Press, London, 1967).

    Book  Google Scholar 

  7. Traub, W., and Yonath, A., J. Mol. Biol., 16, 404 (1966).

    Article  CAS  Google Scholar 

  8. Traub, W., and Yonath, A., J. Mol. Biol., 25, 351 (1967).

    Article  CAS  Google Scholar 

  9. Scatturin, A., Del Pra, A., Tamburro, A. M., and Scoffone, E., Chem. Ind., 49, 970 (1967).

    Google Scholar 

  10. Corey, R. B., and Pauling, L., Proc. Roy. Soc., B, 141, 10 (1953).

    Article  ADS  CAS  Google Scholar 

  11. Leung, Y. C., and Marsh, R. E., Acta Cryst., 11, 17 (1958).

    Article  CAS  Google Scholar 

  12. Ramachandran, G. N., Sasisekharan, V., and Thathachari, Y. T., Collagen (edit. by Ramanathan, N.), 81 (Interscience, New York, 1962).

    Google Scholar 

  13. Ramakrishnan, C., and Ramachandran, G. N., Biophys. J., 5, 909 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Edsall, J. T., Flory, P. J., Liquori, A., Kendrew, J. C., Nemethy, G., Ramachandran, G. N., and Scheraga, H. A., J. Mol. Biol., 15, 399 (1965).

    Article  Google Scholar 

  15. Burge, R. E., Cowan, P. M., and MacGavin, S., Recent Advances in Gelatin and Glue Research (edit. by Stainsby, G.), 25 (Pergamon Press, London, 1958).

    Google Scholar 

  16. Ramachandran, G. N., Treatise on Collagen, 1, 103 (edit. by Ramachandran, G. N.) (Academic Press, London, 1967).

    Google Scholar 

  17. Hannig, K., and Nordwig, A., Treatise on Collagen, 1, 73 (edit. by Ramachandran, G. N.) (Academic Press, London, 1967).

    Google Scholar 

  18. Cowan, P. M., and McGavin, S., Nature, 176, 501 (1965).

    Article  ADS  Google Scholar 

  19. Traub, W., Shmueli, U., Suwalsky, M., and Yonath, A., Conformation of Biopolymers, 2, 449 (edit. by Ramachandran, G. N.) (Academic Press, London, 1967).

    Book  Google Scholar 

  20. Oriel, P. J., and Blout, E. R., J. Amer. Chem. Soc., 88, 2041 (1966).

    Article  CAS  Google Scholar 

  21. Engel, J., Kurtz, J., Katchalski, E., and Berger, A., J. Mol. Biol., 17, 255 (1966).

    Article  CAS  Google Scholar 

  22. Rao, N. V., and Harrington, W. F., J. Mol. Biol., 21, 577 (1966).

    Article  CAS  Google Scholar 

  23. Englander, S. W., Biochemistry, 2, 798 (1963).

    Article  CAS  Google Scholar 

  24. Marvin, D. A., Spencer, M., Wilkins, M. H. F., and Hamilton, L. D., J. Mol. Biol., 3, 547 (1961).

    Article  CAS  Google Scholar 

  25. Davies, D. R., and Rich, A., Acta Cryst., 12, 97 (1959).

    Article  CAS  Google Scholar 

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TRAUB, W., YONATH, A. & SEGAL, D. On the Molecular Structure of Collagen. Nature 221, 914–917 (1969).

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