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Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin

Nature volume 221, pages 618–622 (1969)Cite this article

Abstract

2,3-Diphosphoglycerate is present in the red cells of many species at about equimolar concentration to haemoglobin. It lowers the oxygen affinity and thus facilitates oxygen unloading because it is preferentially bound to deoxyhaemoglobin in the ratio of one mole per tetramer.

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Authors and Affiliations

  1. Department of Biochemistry, Columbia University, College of Physicians and Surgeons, New York

    REINHOLD BENESCH & RUTH E. BENESCH

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  1. REINHOLD BENESCH
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  2. RUTH E. BENESCH
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BENESCH, R., BENESCH, R. Intracellular Organic Phosphates as Regulators of Oxygen Release by Haemoglobin. Nature 221, 618–622 (1969). https://doi.org/10.1038/221618a0

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