Abstract
XANTHINE oxidase (xanthine: oxygen oxidoreductase, EC 1.2.3.2) catalyses the oxidation of hypoxanthine to xanthine and of xanthine to uric acid. The increased excretion of hypoxanthine and xanthine, and the very low concentrations of uric acid in blood and urine which are characteristic of xanthinuria, were first reported by Dent and Philpot1 and by Dickinson and Smellie2. Gross deficiency of jejunal and hepatic xanthine oxidase was reported by Watts et al.3 and by Engelman et al.4. We report here the occurrence of crystalline material resembling xanthine and hypoxanthine in the striped muscle of two xanthinuric patients.
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References
Dent, C. E., and Philpot, G. R., Lancet, i, 182 (1954).
Dickinson, C. J., and Smellie, J. M., Brit. Med. J., ii, 1217 (1959).
Watts, R. W. E., Engelman, K., Klinenberg, J. R., Seegmiller, J. E., and Sjoerdsma, A., Nature, 201, 392 (1964).
Engelman, K., Watts, R. W. E., Klinenberg, J. R., Sjoerdsma, A., and Seegmiller, J. R., Amer. J. Med., 37, 839 (1964).
Liddle, L., Seegmiller, J. E., and Laster, L., J. Lab. and Clin. Med., 54, 903 (1959).
Chalmers, R. A., and Watts, R. W. E., Analyst, 93, 354 (1968).
Chalmers, R. A., and Watts, R. W. E., Analyst (in the press).
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CHALMERS, R., WATTS, R., PALLIS, C. et al. Crystalline Deposits in Striped Muscle in Xanthinuria. Nature 221, 170–171 (1969). https://doi.org/10.1038/221170a0
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DOI: https://doi.org/10.1038/221170a0
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