Abstract
CERTAIN transmissible infectious agents may remain in tissues for prolonged periods before leading to pathological processes and disease (“slow” infections)1. Riley agent (lactate dehydrogenase elevating virus)2 is associated with many experimental tumours of mice and is said to persist in the blood of an infected animal throughout life3. Because scrapie belongs to the group of “slow” infections and Pattison and Jones4 have recently claimed that scrapie may sometimes result from inoculation of mouse tumour material into normal mice, we have tried to determine whether prolonged infection with Riley agent might initiate the scrapie process, especially as mouse scrapie has certain features resembling astroglial neoplasia5. Although Riley agent was not found to produce scrapie, we obtained some highly unexpected results.
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FIELD, E., ADAMS, D. & JOYCE, G. Neurological Illness after Inoculation of Tissue from Tumour Bearing Animals. Nature 221, 1265–1266 (1969). https://doi.org/10.1038/2211265b0
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DOI: https://doi.org/10.1038/2211265b0
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