AFTER the destruction of sympathetic nerve endings by 6-hydroxydopamine1,2, there is a compensatory increase in the catecholamine synthesis and tyrosine hydroxylase activity in the adrenal gland3. We have examined the actions of reserpine and phenoxybenzamine on adrenal tyrosine hydroxylase activity. These drugs, like 6-hydroxydopamine2, interfere with postganglionic sympathetic transmission, but by different mechanisms4–6. We also studied the alterations of this enzyme in an embryologically related tissue, the superior cervical sympathetic ganglion. Reserpine and phenoxybenzamine increased the activity of adrenal tyrosine hydroxylase, and reserpine also increased the activity of tyrosine hydroxylase in the superior cervical ganglion. This increase in enzyme activity was prevented by interruption of nerve impulses by decentralization.
Tranzer, J. P., and Thoenen, H., Experientia, 24, 155 (1968).
Thoenen, H., and Tranzer, J. P., Naunyn-Schmiedebergs Arch. Pharmak. Exp. Path., 261, 271 (1968).
Mueller, R. A., Thoenen, H., and Axelrod, J., Science, 163, 468 (1969).
Carlsson, A., Rosengren, E., Bertler, A., and Nilsson, J., in Psychotropic Drugs, 6, 363 (Elsevier, Amsterdam, 1957).
Nickerson, M., and Gump, W. S., J. Pharmacol. Exp. Therap., 97, 25 (1949).
Iggo, A., and Vogt, M., J. Physiol., 150, 114 (1960).
Levitt, M., Gibb, J. W., Daly, J. W., Lipton, M., and Udenfriend, S., Biochem. Pharmacol., 16, 1313 (1967).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).
Anton, A. H., and Sayre, D. F., J. Pharmacol. Exp. Therap., 138, 360 (1962).
Euler, U. S. von, and Lishajko, F., Acta Physiol. Scand., 51, 348 (1961).
Sedvall, G. C., and Kopin, I. J., Biochem. Pharmacol., 16, 39 (1967).
Dairman, W., Gordon, R., Spector, S., Sjoerdsma, A., and Udenfriend, S., Mol. Pharmacol., 4, 457 (1968).
About this article
Cite this article
THOENEN, H., MUELLER, R. & AXELROD, J. Increased Tyrosine Hydroxylase Activity after Drug-induced Alteration of Sympathetic Transmission. Nature 221, 1264 (1969). https://doi.org/10.1038/2211264a0
Cholinergic and peptidergic neurotransmission in the adrenal medulla: A dynamic control of stimulus‐secretion coupling
IUBMB Life (2020)
Chemical sympathectomy attenuates lipopolysaccharide-induced increase of plasma cytokine levels in rats pretreated by ACTH
Journal of Neuroimmunology (2019)
Impact of Chromogranin A deficiency on catecholamine storage, catecholamine granule morphology and chromaffin cell energy metabolism in vivo
Cell and Tissue Research (2016)
Stress-induced changes in adrenal neuropeptide Y expression are regulated by a negative feedback loop
Journal of Neurochemistry (2013)
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis
Proceedings of the National Academy of Sciences (2002)