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Increased Deiodination of L-Thyroxine and L-Triiodothyronine by Liver Microsomes from Rats treated with Phenobarbital

Nature volume 221, pages 1262–1263 (1969)Cite this article

Abstract

PHENOBARBITAL given to rats in doses known to increase the formation of hepatic smooth endoplasmic reticulum (SER) and drug-metabolizing enzymes also increases hepatocellular binding of thyroxine (T4)1 and its deiodinative and biliary clearance2. Subcellular fractionation of liver homogenates suggested that the increased hepatocellular binding could be attributed to the microsomal membranes3. Because hepatic microsomes contain a specific iodothyronine deiodinase4–7, we attempted to determine whether the increased deiodination observed in vivo could be related to increased microsomal activity.

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Authors and Affiliations

  1. Endocrine Research Laboratory, Division of Medicine, Montefiore Hospital and Medical Center,

    H. L. SCHWARTZ, V. KOZYREFF, M. I. SURKS & J. H. OPPENHEIMER

  2. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, 10467

    H. L. SCHWARTZ, V. KOZYREFF, M. I. SURKS & J. H. OPPENHEIMER

Authors
  1. H. L. SCHWARTZ
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  2. V. KOZYREFF
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  3. M. I. SURKS
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  4. J. H. OPPENHEIMER
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SCHWARTZ, H., KOZYREFF, V., SURKS, M. et al. Increased Deiodination of L-Thyroxine and L-Triiodothyronine by Liver Microsomes from Rats treated with Phenobarbital. Nature 221, 1262–1263 (1969). https://doi.org/10.1038/2211262a0

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