Abstract
INDUCTION of tumours by viruses in experimental animals requires infection early in life, and many viruses induce tumours only in the newly born. Prevention of virus-induced neoplasia by immunological means has been reported1–8. In domestic chickens a lymphoproliferative disease called Marek's disease (MD)9 has drawn considerable attention and it has been proposed that the cause is a herpes-like virus10,11. Natural exposure of young chicks to MD virus causes gross lesions before the age of 12 weeks, thereby increasing mortality and condemnation at slaughter. Increasing resistance with age has been reported in birds experimentally exposed to MD12–14. In young chickens the response to MD virus differs according to the isolate used. The virus is associated with the cells and cannot be separated from them15,16. We describe here the apparent protection of one day old chicks against later infection, by inoculation of the MD agent propagated in tissue culture.
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KOTTARIDIS, S., LUGINBUHL, R. Control of Marek's Disease by the Use of Inoculated Chicken Embryo Fibroblasts. Nature 221, 1258–1259 (1969). https://doi.org/10.1038/2211258a0
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DOI: https://doi.org/10.1038/2211258a0
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