Abstract
Irreversible senescence in fungi—a cytoplasmic condition—may be the result of a breakdown in the maintenance of the accuracy of protein synthesis. Premature senescence in Podospora can be induced by treatments which may reduce the accuracy of amino-acid incorporation. A predicted interrelationship between phenotypic reversion of a base substitution mutation, suppression and ageing is shown in Neurospora.
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HOLLIDAY, R. Errors in Protein Synthesis and Clonal Senescence in Fungi. Nature 221, 1224–1228 (1969). https://doi.org/10.1038/2211224a0
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DOI: https://doi.org/10.1038/2211224a0
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