Abstract
As well as its ability to induce cancer in various tissues, the polycyclic hydrocarbon 3-methylcholanthrene (MCA) is capable of affecting the activity of certain endocrine glands1–3 and altering the metabolism of several hormones4–7. Indirect evidence from several sources6,8–12 indicates that, in various experimental conditions, MCA may be capable of inhibiting, potentiating or mimicking the activity of certain steroid hormones. We have conducted preliminary experiments aimed at testing more rigorously the alleged steroidal activity of MCA. In the experiment reported here, MCA was tested for oestrogenic (uterotrophic) activity in a four point assay using oestrone as the reference standard.
Similar content being viewed by others
Article PDF
References
Huggins, C., and Pollice, L., J. Exp. Med., 107, 13 (1958).
Moon, R. C., J. Nat. Cancer Inst., 32, 461 (1964).
Newman, W. C., and Moon, R. C., Cancer Res., 26, 1938 (1966).
Arcos, J. C., Conney, A. H., and Buu Hoi, N. P., J. Biol. Chem., 236, 1291 (1961).
Jellinck, P. H., and Irwin, L., Nature, 198, 787 (1963).
Glenn, E. M., Lyster, S. C., Bowman, B. J., and Richardson, S. L., Endocrinology, 64, 419 (1959).
Newman, W. C., and Moon, R. C., Endocrinology, 80, 896 (1967).
Hertz, R., and Tullner, W., J. Nat. Cancer Inst., 8, 121 (1947).
Lasnitzki, I., Brit. J. Cancer, 5, 345 (1951).
Jull, J. W., Acta Union Intern. Cancr., 12, 653 (1956).
Jackson, D., and Robson, J. M., J. Endocrinol., 14, 348 (1947).
Huggins, C., Briziarelli, G., and Sutton, H., J. Exp. Med., 109, 25 (1959).
Yang, N. C., Castro, A. J., Lewis, M., and Wong, T. W., Science, 134, 38 (1961).
Huggins, C., and Yang, N. C., Science, 137, 257 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NEWMAN, W., MOON, R. Anti-uterotrophic Response of Immature Mice to 3-Methylcholanthrene. Nature 221, 89 (1969). https://doi.org/10.1038/221089a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/221089a0
This article is cited by
-
Antiestrogenic effect of paradichlorobenzene in immature mice and rats
Archives of Toxicology (2007)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.