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Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog Lung

Abstract

RECENT work1 has established the crucial part played by the pulmonary circulation in the pharmacodynamics of the renin-angiotensin system in the dog. It is the only vascular bed that does not inactivate all or part of the angiotensin II passing through it, and it is the only vascular bed that converts circulating angiotensin I to angiotensin II (refs. 1 and 2). The differences between the metabolism of these peptides by the lungs and by other vascular beds might be a result of differences in the enzymes present in the tissues. This communication describes some of the enzymes in extracts of dog lung that metabolize angiotensins I and II and particularly those catalysing the conversion of angiotensin I to angiotensin II (“converting enzyme”). The enzyme(s) responsible for the inactivation of angiotensin II and angiotensin I are referred to as “destroying enzyme”.

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BAKHLE, Y. Conversion of Angiotensin I to Angiotensin II by Cell-free Extracts of Dog Lung. Nature 220, 919–921 (1968). https://doi.org/10.1038/220919a0

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