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Increased DNA Polymerase Activity in Human Leukaemic Cells

Nature volume 220, pages 713–714 (1968)Cite this article

Abstract

WE recently reported an increased incorporation of 3H-thymidine into DNA of leukaemic granulocytes from human chronic granulocytic leukaemia (CGL) as compared with normal granulocytes1. There is evidence to the effect that this increased incorporation is a result of de novo synthesis of DNA by a semi-conservative mechanism2. We have investigated an in vitro DNA polymerase system in searching for enhanced priming activity of isolated leukaemic DNA, or for a difference in the activity of DNA polymerase (DNA nucleotidyltransferase (EC 2.7.7.7)). Bardos et al.3 have reported increased priming activity of DNA isolated from a variety of malignant tissues compared with DNA isolated from normal tissue. An example of increased DNA polymerase activity has been demonstrated after partial hepatectomy in rats4.

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References

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Duke University Medical Center, Durham, North Carolina

    PETER OVE

  2. Department of Medicine, Duke University Medical Center, and Veterans' Administration Hospital, Durham, North Carolina

    WILLIAM B. KREMER & JOHN LASZLO

Authors
  1. PETER OVE
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  2. WILLIAM B. KREMER
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  3. JOHN LASZLO
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OVE, P., KREMER, W. & LASZLO, J. Increased DNA Polymerase Activity in Human Leukaemic Cells. Nature 220, 713–714 (1968). https://doi.org/10.1038/220713a0

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