Role of Interferon in Experimental Mouse Malaria

Article metrics


INTERFERENCE with experimental plasmodial infections by associated infectious agents has been previously described (West Nile virus1; Chlamydia psittaci, an ornithosis strain2; bacterial endotoxin3), but observations were not made to determine whether the effects observed were mediated by interferon. These reports and our own findings4 of induction of interferon by P. berghei infection in mice led us to further investigation of mouse malaria in relation to interferon.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Yoeli, M., Becker, Y., and Bernkopf, H., Harefuah, 49, 116 (1955).

  2. 2

    Jacobs, H. R., Proc. Soc. Exp. Biol. and Med., 95, 372 (1957).

  3. 3

    Martin, L. K., Einheber, A., Sadun, E. H., and Wren, R. E., Exp. Parasitol., 20, 186 (1967).

  4. 4

    Huang, K.-Y., Schultz, W. W., and Gordon, F. B., Science (in the press).

  5. 5

    Youngner, J. S., Scott, A. W., Hallum, J. V., and Stinebring, W. R., J. Bacteriol., 92, 862 (1966).

  6. 6

    Hopps, H. E., Kohno, S., Kohno, N., and Smadel, J. E., Bact. Proc., 115 (Abstract V5) (1964).

  7. 7

    Hanna, L., Merigan, T. C., and Jawetz, E., Proc. Soc. Exp. Biol. and Med., 122, 417 (1966).

  8. 8

    Merigan, T. C., and Hanna, L., Proc. Soc. Exp. Biol. and Med., 122, 421 (1966).

  9. 9

    Jenkin, H. M., and Lu, Y. K., Amer. J. Ophthalmol., 63, 110 (1967).

  10. 10

    Rytel, M. W., and Jones, T. C., Proc. Soc. Exp. Biol. and Med., 123, 859 (1966).

  11. 11

    Freshman, M. M., Merigan, T. C., Remington, J. S., and Brownlee, I. E., Proc. Soc. Exp. Biol. and Med., 123, 862 (1966).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

SCHULTZ, W., HUANG, K. & GORDON, F. Role of Interferon in Experimental Mouse Malaria. Nature 220, 709–710 (1968) doi:10.1038/220709a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.